In a Group D match in Uyo, defending champions Zamalek faced former champions Enyimba, resulting in a 2-2 draw.
Zamalek will be disappointed after letting go of a two-goal lead, with goals from Seifeddine Jaziri and Omar Faraj equalized by Ufere Chukwu and Ifeanyi Ihemekwele.
As a result, Zamalek remains at the top of the group with four points, while Enyimba moves to third place with their first point.
In Group A, Bravos do Maquis narrowly defeated Sfaxien FC 3-2 at Estadio 11 Novembro in Luanda. Keoikantse Mosiatlhaga opened the scoring for Bravos, but Mohamed Dhuaoui quickly equalized.
Bravos regained the lead through Joaquim Paciencia and Francisco Matonco before Hazem Hassen narrowed the deficit in the second half.
Despite opportunities for both teams, the match concluded 3-2 in favor of Bravos, placing them second in the group behind SC Constantine, who also secured a win against Simba SC. Sfaxien FC remains at the bottom of the standings.