The match took place at the national stadium in Accra. Kotoko took the lead twice in the first half with goals from Emmanuel Antwi and Albert Amoah. However, Johnmark Atule equalised for Kwara twice, making it 2-2 at halftime.

In the second half, Kotoko pulled ahead again with goals from Joseph Ablorh and Amoah, who scored from a penalty. Kwara managed to score again when Abdulraheem Shola found the net five minutes before the end.

The second leg is on September 28 in Abeokuta, about 100 kilometres north of Lagos.

Kotoko seeks to reclaim its strength in African football, having reached the CAF Champions League finals seven times and winning twice between 1967 and 1993. They also lost the first Confederation Cup final in 2004 to Hearts of Oak.

Kwara competes in the Confederation Cup for the third time, previously exiting the qualifying phase against the Moroccan team Renaissance Berkane.

In another match, Abia Warriors drew 1-1 with Malian club Djoliba, thanks to a goal from Chukwuemeka Obioma.

South African team Kaizer Chiefs lost 1-0 to Angolan club Kabuscorp, with Edo Bokota scoring. Chiefs have only won one trophy in the last ten seasons, the FA Cup final against Orlando Pirates, as coach Nasreddine Nabi couldn’t travel to Angola, leaving assistant coaches in charge.

Results – First Preliminary Round (First legs)

16 September
Forestiers FC (Seychelles) 1–0 15 de Agosto (Equatorial Guinea)

19 September
Welayta Dicha (Ethiopia) 0–0 Al-Ittihad (Libya)
Aigle Royal (Cameroon) 0–1 San Pedro (Côte d’Ivoire)
USFA (Burkina Faso) 1–0 Gbohloe-su (Togo)
Nigelac (Niger) 0–0 Olympique de Safi (Morocco)

20 September
El Merriekh Bentiu (South Sudan) 0–2 Azam (Tanzania)
Flambeau du Centre (Burundi) 2–1 Al Akhdar (Libya)
Madani (Sudan) 1–0 Étoile Sportive du Sahel (Tunisia)
FC 105 Libreville (Gabon) 2–0 ZESCO United (Zambia)
Bhantal (Senegal) 0–3 Hafia (Guinea)
Singida Black Stars (Tanzania) 1–0 Rayon Sports (Rwanda)
Stade Tunisien (Tunisia) 2–0 SNIM (Mauritania)
Kabuscorp (Angola) 1–0 Kaizer Chiefs (South Africa)
NEC FC (Uganda) 2–2 Nairobi United (Kenya)

21 September
Generation Foot (Senegal) 1–1 Académie de FAD (Côte d’Ivoire)
Black Man Warrior (Liberia) 0–0 Coton FC (Benin)
Abia Warriors (Nigeria) 1–1 Djoliba (Mali)
Asante Kotoko (Ghana) 4–3 Kwara United (Nigeria)
15 de Agosto (Equatorial Guinea) 4–0 Forestiers FC (Seychelles)
Primeiro de Agosto (Angola) 1–2 Otohô d’Oyo (Congo)
Port (Djibouti) 1–2 KMKM (Zanzibar)
Dekedda (Somalia) 1–0 Zamala Ruwaba (Sudan)
Ferroviário Maputo (Mozambique) 1–1 AS Fanalamanga (Madagascar)
Mighty Wanderers (Malawi) 1–0 Jwaneng Galaxy (Botswana)

Second-leg dates: 26–28 September 2025.